February 15 » While on board the Niña, Christopher Columbus writes an open letter (widely distributed upon his return to Portugal) describing his discoveries and the unexpected items he came across in the New World.
March 4 » Explorer Christopher Columbus arrives back in Lisbon, Portugal, aboard his ship Niña from his voyage to what are now The Bahamas and other islands in the Caribbean.
May 4 » Pope Alexander VI divides the New World between Spain and Portugal along the Line of Demarcation.
September 9 » Battle of Krbava Field, a decisive defeat of Croats in Croatian struggle against the invasion by the Ottoman Empire.
September 26 » Pope Alexander VI issues the papal bull Dudum siquidem to the Spanish, extending the grant of new lands he made them in Inter caetera.
November 3 » Christopher Columbus first sights the island of Dominica in the Caribbean Sea.
April 2 » Spanish explorer Juan Ponce de León first sights land in what is now the United States state of Florida.
April 30 » Edmund de la Pole, Yorkist pretender to the English throne, is executed on the orders of Henry VIII.
June 6 » Battle of Novara. In the Italian Wars, Swiss troops defeat the French under Louis II de la Trémoille, forcing them to abandon Milan; Duke Massimiliano Sforza is restored.
August 16 » Battle of the Spurs (Battle of Guinegate): King Henry VIII of England and his Imperial allies defeat French Forces who are then forced to retreat.
September 9 » James IV of Scotland is defeated and dies in the Battle of Flodden, ending Scotland's involvement in the War of the League of Cambrai.
October 7 » War of the League of Cambrai: Spain defeats Venice.
When copying data from this family tree, please include a reference to the origin: Charles Olson, "Olson's Tree", database, Genealogy Online (https://www.genealogieonline.nl/olsons-tree/P12152.php : accessed January 4, 2026), "Antoinette de Bourbon-Vendome Duchess of Guise (1493-1583)".
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