January 16 » The first grammar of the Spanish language (Gramática de la lengua castellana) is presented to Queen Isabella I.
April 17 » Spain and Christopher Columbus sign the Capitulations of Santa Fe for his voyage to Asia to acquire spices.
September 6 » Christopher Columbus sails from La Gomera in the Canary Islands, his final port of call before crossing the Atlantic Ocean for the first time.
October 12 » Christopher Columbus's first expedition makes landfall in the Caribbean, specifically in The Bahamas.
December 5 » Christopher Columbus becomes the first European to set foot on the island of Hispaniola (now Haiti and the Dominican Republic).
December 25 » The carrack Santa María, commanded by Christopher Columbus, runs onto a reef off Haiti due to an improper watch.
March 4 » Hernán Cortés arrives in Mexico in search of the Aztec civilization and its wealth.
July 10 » Zhu Chenhao declares the Ming dynasty's Zhengde Emperor a usurper, beginning the Prince of Ning rebellion, and leads his army north in an attempt to capture Nanjing.
August 10 » Ferdinand Magellan's five ships set sail from Seville to circumnavigate the globe. The Basque second-in-command Juan Sebastián Elcano will complete the expedition after Magellan's death in the Philippines.
August 15 » Panama City, Panama is founded.
September 20 » Ferdinand Magellan sets sail from Sanlúcar de Barrameda with about 270 men on his expedition to circumnavigate the globe.
November 8 » Hernán Cortés enters Tenochtitlán and Aztec ruler Moctezuma welcomes him with a great celebration.
When copying data from this family tree, please include a reference to the origin: Peter John Oswald, "Pop Oswald Tree", database, Genealogy Online (https://www.genealogieonline.nl/pop-oswald-tree/P30968.php : accessed February 13, 2026), "Lorenzo Ii of MEDICI (1492-1519)".
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