April 18 » Trial of Martin Luther begins its second day during the assembly of the Diet of Worms. He refuses to recant his teachings despite the risk of excommunication.
April 23 » Battle of Villalar: King Charles I of Spain defeats the Comuneros.
April 29 » Swedish War of Liberation: Swedish troops defeat a Danish force in the Battle of Västerås.
May 25 » The Diet of Worms ends when Charles V, Holy Roman Emperor, issues the Edict of Worms, declaring Martin Luther an outlaw.
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