About the town » Walterboro, Colleton County, South Carolina, United States

Walterboro is a city in Colleton County, South Carolina, United States. The population was 5,398 at the 2010 census. It is the county seat of Colleton County. Walterboro is located 48 miles (77 km) west of Charleston and is located near the ACE Basin region in the South Carolina Lowcountry.