January 23 » The deadliest earthquake in history, the Shaanxi earthquake, hits Shaanxi province, China. The death toll may have been as high as 830,000.
February 14 » Coronation of Akbar.
February 14 » Thomas Cranmer is declared a heretic.
September 15 » Departing from Vlissingen, ex-Holy Roman Emperor Charles V returns to Spain.
November 5 » Second Battle of Panipat: Fought between the forces of Hem Chandra Vikramaditya, the Hindu king at Delhi and forces of Muslim Emperor Akbar.
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