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The identity of Isaac II's first wife is unknown, but her name, Herina (i.e., Irene), is found on the necrology of Speyer Cathedral, where their daughter Irene is interred. (However, it would have been extremely unusual for a mother and daughter to bear the same name, unless the mother's name was monastic.)[5] Isaac's wife may have been a member of the Palaiologos family.
Note 1: The first wife of Isaac II is usually considered to be a Byzantine noblewoman of unknown name. In an Italian edition of the chronicle of Nicetas Choniates "Greatness and catastrophe of Byzantium" can be found an interesting note to the XIV Book. The names of Isaac II's first wife and eldest daughter, unknown to Byzantine sources, are found in an obituary in the Cathedral of Speyer (Germany) (the Pantheon of German kings) where it can be found the second daughter of Isaac II, Irene/Maria, wife of Philip of Suabia; in this text Irene/Maria is said daughter of Isaac and Irene (there is reference to the following article: R. Hiestand, Die erste Ehe Isaaks II. Angelos und seine Kinder, in Jahrbuch der Osterreichischen Byzantinisk, XLVII 1997 pp. 199-208). This Irene could be identified with the daughter of Georg Paleologus Ducas Comnenus; the son of this one, Andronicus Paleologus Comnenoducas is known as gambrox (gamma alpha mu beta rho o x) of Isaac II.
Note 2: Morris Bierbrier's "Medieval and royal genealogy update" column in the March 1999 issue of _Genealogists' Magazine_ gives a partial summary of the article by Hiestand; this is where I learned of its existence. Hiestand's article is of special interest because it explores the hypothesis that the first wife of Isaac II is a member of the Palaiologos family, perhaps the daughter of Georgios Palaiologos Komnenodoukas, megas hetaireiarches. This is based on a reference to Andronikos Palaiologos (probable son of Georgios) as beloved gambros (brother-in-law or son-in-law, though the former is more likely) of Emperor Isaac II in a document (from 1191, I think) printed in A. Papadopoulos- Kerameus's _Analekta ..._, II, Petersburg, 1894, p. 362. Unfortunately, the genealogy of the early Palaiologoi is somewhat murky.
SOURCE: Wikipedia - https://en.wikipedia.org/wiki/Isaac_II_Angelos
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