Clemson is a college town located in Pickens and Anderson counties in the U.S. state of South Carolina. The city is best known as the home to the Clemson University campus. The population was 13,905 at the 2010 census and center of an urban cluster with a total population of 42,199. Clemson is part of the Greenville-Spartanburg-Anderson, South Carolina Combined Statistical Area. Most of the city is in Pickens County, which is part of the Greenville-Mauldin-Easley Metropolitan Statistical Area. A small portion is in Anderson County, which is part of the Anderson Metropolitan Statistical Area.