Hij is getrouwd met Isabel Tellez de MENESES.rond 1324.
João Afonso de Albuquerque, (ca. 1304-28 September 1354), Juan Alfonso de Alburquerque in Spanish and knicknamed "o do Ataúde", 6th Lord of Alburquerque, was a member of the highest ranks of the nobility of the Kingdom of Portugal, an astute politician, and descendant from the royal houses of both Portugal and Castile, although through illegitimate lines.
Count of Alburquerque, Lord of Azagala, Codosera, Alconchel, Medellín, Meneses and Tiedra, he was the Alférez of King Alfonso XI of Castile and Leon (1333-1336), Chancellor of Castile between 1350 and 1353, and Mayordomo mayor of Infante Peter, later King Peter I of Castile, who is suspected of having him poisoned in 1354.
His father, Afonso Sanches, was the firstborn and favorite son of King Dinis I of Portugal who had him out of wedlock with Aldonza Rodrigues Telha,. Teresa Martins de Meneses, his mother, was the daughter of João Afonso Teles de Meneses, the first count of Barcelos, and of Teresa Sánchez, an illegitimate daughter of Sancho IV the Brave, king of Castile and León. Teresa survived her husband by almost twenty years.
João Afonso de Albuquerque was raised in Lisbon at the house of João Simão de Urrô who in 1314 gave him certain properties in the city and in Alenquer.
Between 1323 and 1324, he married his cousin Isabel Téllez de Meneses, the tenth Lady of Meneses, and daughter of Tello Alfonso de Meneses and Maria of Portugal, granddaughter of Afonso III of Portugal.
Only one son was born of this marriage:
Martin Gil de Alburquerque (ca. 1325-1365) became lord of Alburquerque at the death of his father and was the adelantado of Murcia. He was executed by order of Peter the Cruel in 1365 and buried at the same monastery as his parents. His death marked the end of the principal line of this lineage and his estates were incorporated by Peter I in the crown.
João Afonso de Albuquerque had several children out of wedlock with Maria Rodrigues Barba, daughter of Rui Martins Barba and Iria Martins Alardo:
Fernando Afonso de Albuquerque (c. 1327-1387). Lord of Vila Nova de Anços and Master of the Order of Santiago, with illegitimate issue.
Beatriz Afonso de Albuquerque. She married João Afonso Telles de Meneses, 6th Count of Barcelos and Admiral of Portugal, who died in the Battle of Aljubarrota.
Maria Afonso de Albuquerque, the wife of Gonçalo Telles de Meneses, first Count of Neiva and Lord of Faria and brother of the husband of her sister Beatriz.
He had another son with María Gil:
Pedro Gil de Alburquerque.